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And that was fantastic. Basile is also obviously very intelligent and dedicated. He taught himself everything and ended up publishing beautiful papers on the cochlea, in a retina lab! That was very impressive.

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I have no doubt that Basile will continue to make important contributions and will become a leader in his field. Tarchini joined the JAX faculty in The complex genetics of musical talent Are musicians born or made? Exploring the genetics of musical ability using absolute pitch. Tarchini is also an accomplished jazz musician who once considered taking the path of the professional performer instead of the scientist.

A musician-scientist who studies hearing? And in fact, his research interests, while staying in the inner ear, are moving to include the vestibular system, which is located right next to the cochlea. Tarchini has already shown he can boldly and successfully shift his research focus.

The Mechanism of Hearing

Stay tuned for interesting discoveries. What is Personalized Medicine? Genetics vs. Why Mice? Did you hear that sound? If so, you can thank your stereocilia. The auditory epithelium of a young postnatal mouse. Sound deflects these stereocilia to open gated channels, and the depolarization of the green hair cells results in the release of neurotransmitters at the base of the cell, which is captured by the red nerve terminals, and then relayed to the brain.

The Journey of Sound

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Sep 23 - Apr 24 - Oct 06 - We have updated our privacy policy. Please take a moment to review it. These are freely accessible for measurements, thus being especially well-suited for analyses. During the process of hearing, a sound receiver is set in motion by sound waves. In the case of humans, the eardrum acts as a sound receiver; in the case of flies, this task is fulfilled by the outer segments of the antenna.

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This stretching is coupled with an ion channel in the cell membrane. When the channel opens, it allows charged molecules to flow into the cell, as a result of which an electrical impulse — a neuronal signal — is triggered. Fruit fly Drosophila melanogaster.

Basic Mechanisms Underlying Noise-Induced Hearing Loss | SpringerLink

At this point, the mechanic amplifier comes into play. In the model, the coupling between vibrating body and channel is represented by a spring.

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This causes the spring to relax and makes the movement easier. This, on the other hand, retroacts on the antenna — it swings out wider as the channels open. The system needs energy to close the channels again and to stretch the spring.

The scientists were able to show that this is realized by means of small movement motors. In further experiments, the scientists were able to show that the motors work most effectively with low sounds — with low sounds, a maximal amplification is achieved. If the ear is stimulated at a certain frequency, the sensitivity to this frequency is increased with each oscillation — as is the case with a swing that is pushed with each swinging.